To solve the problem of a large deformation measurement by using the Digital Image Correlation (DIC) method, a DIC method based on seed points is presented. After dividing subsets in the reference image, one point is chosen as the seed point and is matched firstly. According to the deformation continuity of adjacent stages of the image, an improved integer pixel search method is proposed to guarantee that the seed point can be matched successfully even in a large deformation situation. Once the seed point is matched, it can be used to calculate the initial correlation parameters of its four neighbor points according to the deformation continuity of neighbor points in one stage. The above progress repeats until all the points are matched. A rigid rotation experiment and a tensile test are carried out to verify the proposed method. Measurement results for 40° rotation and large deformation up to 113% confirm the validity of the method.