Although small nucleolar RNAs(snoRNAs)are well-known for guiding 2′-O-methylation and pseudouridine modification on ribosomal RNAs and small nuclear RNAs, their additional functions have remained largely undefined. Liu and colleagues developed snoKARR-seq to map transcriptome-wide snoRNA targets, and discovered an unexpected role of snoRNA: SNORA73 simultaneously binds to the target mRNA and the 7SL RNA of the signal recognition particle to form ternary interactions that facilitate the secretion of the encoded protein.