ObjectiveTo investigate whether coronary stenosis severity was correlated with CT angiography (CTA)-derived quantitative parameters and serum total bilirubin (TBIL), homocysteine (Hcy) and alanine aminotransferase (ALT).MethodsClinical data of 132 patients who underwent coronary angiography in the Second Affiliated Hospital of Chengdu Medical College from January 2020 to August 2022 were retrospectively analyzed. According to the degree of angiographic coronary stenosis, patients were divided into mild group (53 cases), moderate group (46 cases) and severe group (33 cases). CTA-derived quantitative parameters, including reconstruction index (RI), plaque burden and diameter stenosis, and serum levels of TBIL, Hcy, ALT were compared among the three groups. The relationship between CTA-derived quantitative parameters and serum measurements in patients with moderate or severe coronary stenosis was evaluated by Pearson correlation coefficient analysis, and receiver operating characteristic (ROC) curve was applied to analyze the diagnostic value of the combination of these indexes on moderate or severe coronary stenosis.ResultsRI, plaque burden, diameter stenosis, serum Hcy and ALT increased gradually across mild, moderate and severe groups, and the serum TBIL level in severe group was lower than that in mild group and moderate group (all P<0.05). Serum Hcy level correlated positively with diameter stenosis in moderate and severe group, and ALT was strongly related to CTA-derived diameter stenosis in severe group (P<0.05). Serum TBIL level was negatively correlated with CTA-derived plaque burden in moderate group (P<0.05). Combination of diameter stenosis, RI, serum TBIL, Hcy, ALT and plaque burden provided a good diagnostic value for moderate to severe coronary stenosis (AUC=0.948).ConclusionSerum Hcy, TBIL and ALT levels are closely correlated with CTA-derived quantitative parameters. These measurements may have clinical relevance in the preventive and therapeutic decision-making for patients with coronary artery disease.