ObjectiveTo explore the efficacy of modified Yishen Jianpei decoction combined with Jinshuibao in patients with chronic glomerulonephritis (CGN) and its influence on immunomodulatory factors.MethodsA total of 96 CGN patients in the emergency internal medicine department of our hospital from February 2020 to February 2024 were selected as the research subjects. They were randomly divided into the reference group (treated with Jinshuibao) and the combined group (treated with modified Yishen Jianpi decoction combined with Jinshuibao), with 48 cases in each group. After treatment, the clinical efficacy, inflammatory levels, immunomodulatory factors, renal function, renal fibrosis indicators and the occurrence of adverse reactions were compared between the two groups.ResultsAfter treatment, the total effective rate of the combined group was higher than that of the reference group (89.58% vs. 66.67%, P<0.05). The levels of C-reactive protein, erythrocyte sedimentation rate, white blood cell count, interleukin-6, interleukin-2 and tumor necrosis factor-α in the combined group were lower than those in the reference group (P<0.05), and the level of interleukin-4 was higher than that in the reference group (P<0.05). The serum creatinine, blood urea nitrogen, 24-hour urine protein quantification and urine red blood cell count in the combined group were lower than those in the reference group(P<0.05). The levels of laminin, type Ⅳ collagen and tissue metalloproteinase inhibitor-1 in the combined group were lower than those in the reference group (P<0.05). There was no statistically significant difference in the occurrence of adverse reactions between the two groups (P>0.05).ConclusionModified Yishen Jianpi decoction combined with Jinshuibao can improve the immune function and renal function of patients with CGN, reduce the degree of renal fibrosis, and has good safety. It is worthy of clinical promotion and application.