The voltage-driven electrowetting prisms often need to be connected to a larger additional power supply device for manual adjustment, which is not conducive to the integration of the electronic control system and the prism device. Meanwhile, it fails to meet the requirement of the small size and portability of the electrowetting liquid prism device in the practical applications requirements. Aimed at the problems above, an electric control system based on STM32 single-chip microcomputer is designed. The low voltage of the DC power supply output is boosted to the required voltage by the boost chopper circuit, and the four output voltages are adjusted according to the demand. The two-liquid prism is driven to the two-dimensional liquid surface deflection, which makes the unit device convenient and quick to use, and easy to control. The model is simulated and analyzed by COMSOL software to verify the correctness.