The existing domestic vanadium oxide uncooled infrared detectors mostly use baffle correction for nonuniformity correction, which leads to complex structure and image interruption, thus affecting the normal use of the detector. In order to expand the usage direction and field of infrared detectors, a new non-uniformity correction method without baffle is proposed in this paper, which combines the non-uniformity correction method based on calibration correction and scene correction to realize the non baffle correction of uncooled infrared detector. The image non-uniformity of a domestic uncooled infrared imaging system using this method is 0.5% after one hour of operation. Experimental results show that this method can achieve nonuniformity correction quickly after the start of correction, and the correction effect is good, and there is no “ghost” problem existing in traditional scene correction methods. This method avoids the image interruption of the infrared imaging system, and helps to reduce the volume and power consumption of the infrared imaging system, and helps for the application of domestic uncooled infrared detectors in various fields such as aerospace, aviation, and weapon equipment.