In order to study high efficiency welding of carbon fiber reinforced thermo-plastic (CFRTP) and metal, the experiment on the connection of CFRTP and Al was carried out by laser-induced Al-Ti-C powder interlayer self-propagating reaction. Reaction mechanism of weld formation in the interlayer self-propagating reaction, microscopic interface and the formation mechanism of CFRTP/Al joint were analyzed. The results show that, the self-propagating reaction starts when the temperature of the interlayer increases to approximately 933K by laser irradiation. The aluminum element melts and entraps the solid Ti to react to form a Ti-Al compound. At high temperatures, the compound continues to react with Ti to form TiC. It also releases heat. At the same time, elemental Ti and C react to generate TiC and release heat. The heat generated by the reaction continues to maintain the reaction of the next layer until the entire interlayer reaction ends to form a good “weld”. These heat makes that the left and right sides of the interlayer of the base material are slightly melted and re-extruded to form a good quality joint. Laser-induced Al-Ti-C interlayer self-propagating high-temperature synthesis connection can realize the high quality connection of CFRTP/Al, which is helpful to realize the lightweight of the vehicle structure.