This paper briefly reviews the operational principles and designs of portable in vivo skin imaging prototypes developed at the Biophotonics Laboratory of the Institute of Atomic Physics and Spectroscopy, University of Latvia. Four types of imaging devices are presented. Multi-spectral imagers ensure distant mapping of specific skin parameters (e.g., distribution of skin chromophores). Autofluorescence photobleaching rate imagers show potential for skin tumor assessment and margin delineation. Photoplethysmography video-imagers remotely detect cutaneous blood pulsations and provide real-time information on the human cardiovascular state. Multimodal skin imagers perform the above-mentioned functions by acquiring several spectral and video images using the same image sensor.