Laser & Optoelectronics Progress, Volume. 62, Issue 5, 0512003(2025)

Accurate Measurement of Liquid-Phase Diffusion Coefficients of L-Serine Using a Composite Liquid-Core Cylindrical Lens

Nan Yang1、*, Yaqing Liu1, and Licun Sun1,2
Author Affiliations
  • 1College of Physics and Electronic Information, Yunnan Normal University, Kunming 650500, Yunnan , China
  • 2Yunnan Key Laboratory of Opto-Electronic Information Technology, Kunming 650500, Yunnan , China
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    The liquid-phase diffusion coefficient of L-serine is a critical parameter for studying the production processes and biological metabolism of related pharmaceuticals. To accurately determine this coefficient, our research group independently designed and fabricated a composite liquid-core cylindrical lens (SLCL-Doublet). This lens consistently demonstrated excellent refractive index resolution exceeding 0.00004 RIU while maintaining good imaging quality across various liquid samples. By leveraging the one-dimensional refractive index resolution capability of the SLCL-Doublet and applying Fick's second law, we utilized the equal-refractive-index thin-layer method to measure the liquid-phase diffusion coefficient of L-serine aqueous solutions at varying concentrations at 298.15 K. The measurement uncertainty was controlled within 0.15 × 10-6 cm2·s-1. This method offers advantages such as simple experimental operation, minimal time requirements, stable instrumentation, and high measurement accuracy, providing an effective solution for the rapid and accurate determination of liquid-phase diffusion coefficients.

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    Nan Yang, Yaqing Liu, Licun Sun. Accurate Measurement of Liquid-Phase Diffusion Coefficients of L-Serine Using a Composite Liquid-Core Cylindrical Lens[J]. Laser & Optoelectronics Progress, 2025, 62(5): 0512003

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    Paper Information

    Category: Instrumentation, Measurement and Metrology

    Received: May. 17, 2024

    Accepted: Jul. 29, 2024

    Published Online: Mar. 12, 2025

    The Author Email:

    DOI:10.3788/LOP241311

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