In order to optimize the laser welding process of bulk metallic glass(BMG) and crystalline metals, a pulsed infrared laser with a maximum average power of 300 W was used to weld Zr-based bulk metallic glass Zr57Nb5Cu15.4Ni12.6Al10 and 440, 304, and 17-4PH stainless steel. The micro-structure, composition, and mechanical properties of experimental welded joints were characterized by material analysis and mechanical testing. Moreover, appropriate laser offset welding process parameters, micro-structure properties, and mechanical properties of welded joints were obtained. The results show that the laser focus shift 0.2 mm~0.3 mm to the side of stainless steel can make the welding evenly and improve the bending strength effectively. The bending strength of bulk metallic glass and 17-4PH joint can reach 339 MPa by appropriate welding process. The laser welded joints of Zr-based bulk metallic glass and stainless steel are mainly divided into melting mixing zone and heat affected zone. Dendritic and granular crystalline structures were found in the melting and mixing zone. The bending strength can be increased by 14%~48% after low temperature annealing treatment. The results of this study have guiding significance for the expansion of Zr- based bulk metallic glass in various fields.