This review focuses on discussing the latest progress in Quartz-enhanced photoacoustic spectroscopy (QEPAS) based trace gas sensing and the trend in the next few years. Fundamentals of QEPAS are described in the beginning and the different QEPAS configurations employing a standard 32.7 kHz quartz tuning fork (QTF) are introduced. Variant methods aiming to improve detection sensitivity and suppress sensor noise level are reported. Moreover, a review regarding developments of customized QTFs for trace gas sensing is present. Novel spectrophone configurations, with which the detection sensitivity is improved by two orders of magnitude, are reviewed. The customized QTFs operating in overtone modes significantly decrease the length of acoustic micro-resonators and realize dual gas simultaneous detection. Finally, the development direction of the QEPAS technique is discussed.