To address the scarcity of large-pixel large-area array detector chips used in star sensors, a design scheme for an imaging module based on domestic high-sensitivity CMOS image sensors (CISs) is proposed. The hardware circuit of the CIS-based star-sensitive imaging module is designed based on the latter's operating principle. An interactive high-speed data-transmission mode for FPGA and DSP software is developed based on an advanced extensible interface bus-control module. Technical parameters related to the practical application of star sensors, i.e., non-uniformity, linearity, dynamic range, and signal-to-noise ratio, are tested. The results show that these indicators of the CIS star-sensitive imaging module satisfy the application requirements for star detection.