In order to explore the influence of the four process parameters of picosecond laser′s single pulse energy, scan times, scan speed, laser repetition frequency on the hydrophobic properties of 2024 aluminum alloy surface, a picosecond laser processing experimental platform was built and a response surface with 4 factors and 3 levels was designed test, the Design-Expert12 software was used to optimize the process parameters to obtain the best combination of process parameters, and verified the accuracy of the regression equation through experiments. According to the results of response surface analysis, the interaction between single pulse energy and scan times, scan times and scan speed, and scan times and laser repetition frequency has significant interaction effects on the surface contact angle. Taking the surface contact angle as the evaluation index, the order of the influence factors of each process parameter on the surface contact angle is: single pulse energy >scanning times>scanning speed>laser repetition frequency. Taking the maximum surface contact angle as the goal, the obtained process parameter combination is: single pulse energy14 μJ, scanning times 7 times, scanning speed 650 mm/s, laser repetition frequency2.2×106 Hz.The predicted surface contact angle is 147.5°, the actual surface contact angle of the test is 150.3°, and the error between the actual value and the predicted value is 1.9%.The test results show that after the picosecond laser process parameters are optimized by the response surface method, the established surface contact angle model has a good predictive ability, the microstructure etching on the surface of aluminum alloy through optimized process parameters can significantly improve its surface hydrophobicity.