Quantum yields for multichannel transition emissions have been determined in Sm3+-doped heavy metal tellurite glass under the pumping of blue lighting emitting diode. To achieve this intention, the necessary fluorescence spectra were measured and calibrated in an integrating sphere with 25.4 cm diameter, which was connected to a CCD detector. Standard halogen lamp was used for calibrating the measurement system and auxiliary halogen lamp was applied to determine the changes in throughput at the different steps of the measurement. The spectral power distribution of the sample under the blue light emitting diode (LED) pumping was derived from the measured spectra firstly, and then the quantum yields for the visible emissions of Sm3+ were calculated based on the distribution and the total quantum yields in visible region is 7.55%.