Tactical laser weapon system is an effective method to destroy unmanned aerial vehicle（UAV）. The destruction efficiency simulation of tactical laser weapon system anti-UAV is presented in this paper. The research background of the tactical laser weapon system is proposed firstly，and then the modeling and simulation of tactical laser weapon anti-UAV destruction is derived by means of deduce the operation flow and destruction theory. Finally，the relationships between destruction distance of system and influence factors are discussed. The results show that the UAV flight altitude and visibility are seriously affected the destruction efficiency of the tactical laser weapon system，and simply increasing laser power has no apparent results on destruction efficiency，the coherent combining and spectral combining technique can improve the laser beam quality and correspondingly enhance the performance of the tactical laser weapon system，the laser weapon’s destruction distance increased by 24%. The study is useful to increase the combat effectiveness of the tactical laser weapon system.