CoFeCrNiV cladding layer was prepared on the surface of automobile welding parts by laser cladding technology. The phase composition, metallographic microstructure and crystallographic characteristics of cladding layer were analyzed respectively, and the hardness and wear resistance of cladding layer were studied. Specific conclusions are as follows: The phase composition of the CoFeCrNiV cladding layer is a single FCC solid solution phase. The lattice distortion of the FCC phase is caused by the V element dissolving in the FCC phase, which promotes the solid solution strengthening effect of the FCC phase. The average microhardness of CoFeCrNiV is 466.7±6.9 HV, 1.9 times higher than that of the 201 matrix, with solution strengthening and dislocation strengthening identified as the primary contributors to its elevated hardness. The average friction coefficient of CoFeCrNiV cladding layer is 0.55. The specific wear rate of CoFeCrNiV cladding layer is 1.91×10-5 mm3/(N·m), approximately 0.32 times that of the substrate, indicating its superior wear resistance. The predominant wear mechanisms for the CoFeCrNiV cladding layer are adhesive and abrasive wear. The study demonstrates that the hardness and wear resistance of CoFeCrNiV coating on 201 stainless steel surface of automobile welded parts can be significantly improved by laser cladding technology.