In order to improve the maximum critical force value and anti-pressed capacity of the liquid crystal panel, by the mechanism analysis of LCD’s light leakage due to the pressing, and combining with the actual production, the main factors are screened using the method of design of experiments (DOE). The DOE results show that the main factors of pressed leakage are the size of the photo spacer (PS), width of black matrix (BM), PS locations, and planarization-layer (PLN) thickness. Improved design experiments are carried out in the actual production process and the results show that the panel anti-pressing capacity can be effectively enhanced by 32.69% by increasing the size of the PS, and its elastic recovery rate can be increased by 4.4%, which can effectively reduce the occurrence of light leakage. Also, by increasing BM width by 3 μm, changing the PS locations’ design from upper right to center and reducing the thickness of PLN by 0.6 μm, the average critical value of the panels’ pressing leakage can be increased by 30.61%, 33.33% and 27.08%, respectively.