［Objective］Interoperability is a major trend in current rail transit development, and the cross-line through operation of trains with different systems is a key operational scenario of such interoperability. Since different train types vary in the number, position, and opening dimensions of passenger compartment doors, the PSD (platform screen door) must be compatible with a variety of train configurations. To better meet the safety, efficiency, and convenience requirements of passenger boarding/alighting in interoperability scenarios, it is necessary to conduct in-depth research on PSD compatibility schemes and structural performance, taking into account the train-type characteristics and load environments of intercity railways, city (suburban) railways, and urban rail transit vehicles.［Method］Taking the cross-line operation of Type-D and CRH6 trains as the research object for the through operation scenario, and based on the characteristics of passenger compartment door positions and parameters for through-operation trains, a side-hinged and telescoping composite compatible PSD typical structure and a full-side compatible PSD layout scheme are proposed. A finite element analysis model is established to calculate and verify the structural strength of compatible typical PSD configuration under the most unfavorable load conditions in an interoperability scenario.［Result & Conclusion］Under the most adverse load condition of passenger crowd pressure, wind load, passenger impact, and seismic forces simultaneous action, the structural strength and stiffness of the compatible PSD fully meet regulatory requirements. The proposed typical door structure effectively resolves the compatibility challenges of PSD systems under the complex working conditions of cross-line operations involving different train-type configurations.