Ce:GAGG scintillation crystal samples were irradiated using a ⁶⁰Co radiation source at a dose rate of 3×10⁵ Rad/h, and the total irradiation doses delivered to the samples were 10⁶, 10⁷, and 10⁸ Rad. The effects of irradiation were investigated by measuring the transmittance, relative light output, energy resolution, and decay time of the Ce:GAGG scintillation crystal samples before and after irradiation. The experimental results showed that after irradiation at a dose of 10⁸ Rad, the transmittance of the crystal remained unchanged in the 450-900 nm, and the lowest transmittance (8.9%) was detected at 320 nm. The light output of the crystal decreased by 1.47%, whereas the energy resolution deteriorated only slightly. The relative light output, energy resolution, and decay time of the crystal did not change significantly. These results confirm the high resistance of the crystal to γ-ray irradiation and demonstrate its broad application prospects in high-dose nuclear radiation detection.