The Gaofen-6 medium resolution wide-width camera （GF6-WFV） is designed with two red-edge bands， which has the potential to monitor chlorophyll a concentration in water. In this study， six typical lakes in eastern China， including Guanting Reservoir， Luhun Reservoir and Baiyangdian Lake， were selected as the study area， and measured spectrum and chlorophyll a concentration data were obtained from 141 sampling points. Based on the measured data， the parameters of four kinds of commonly used semi-empirical inversion models of chlorophyll a concentration were optimized and the model accuracy verified， and the optimal inversion model was selected. The results show that the red edge band Ⅰ （B5：710 nm） and red band （B3： 660 nm） are newly added in GF6-WFV data. Which construct a two-band ratio 2BDA model with high inversion accuracy， correlation coefficient square （R²） is 0.89， the Mean Relative Error （MRE） is 34.71 %， and the Root Mean Square Error （RMSE） is 13.29 mg/m³. The results show that the chlorophyll a concentration in water body can be effectively retrieved by using GF6-WFV image data. The inversion model of chlorophyll a concentration in water body established in this paper based on multi-lake and multi-temporal data has good applicability in typical lake repositories in eastern China.