Selective laser melting (SLM) is a technique in which the powder is melted with laser scanning and solidifies, and the parts are directly fabricated layer by layer. Based on the optimization of process parameters, the single-layer sintering experiment of Ti6Al4V powder was conducted and the guiding range of linear energy density for selective laser melting of Ti6Al4V powder was obtained; on this basis, multi-layer sintering was carried out and the comprehensive analysis was made in combination with metallographic, mechanical properties test and the internal structure of the sample obtained by SEM image. The results indicated that the sample has better mechanical properties when the linear energy density is 0.35–0.55 J/mm: the bending strength is 1 111–1 179 MPa and the hardness is 220–305 HBW. Finally, three-dimensional forming sintering was realized under the optimized process parameters.