Objective :To analysis the distribution, concomitant of the acumination condyloma in anal canal -lower rectum. To evaluate the therapeutic effect of CO2 laser and Nd: YAG laser treatment. Methods: Local anesthesia by lidocaine. Vaporization by CO2 laser directly or by fiber optic Agcl CO2 laser in some cases. Nd: YAG. Laser was also used in vaporization or hemostasis. Some patients with deep lesion were undertaken through anoscope. Re-sults:28 patients were treated 1 to 5 times with efficacy of 96%. The methods are safe, reliable and with no complication. Conclusions:laser therapy has been widely accepted as a simple and effective method to treat acumination condyloma. Nd:YAG laser has its unique advantage in the treatment of acumination condyloma in anal canal - lower rectum, especially its simplicity and efficacy for the lesion in lower rectum through anoscope.