In order to solve the problem of connection molding between dissimilar materials in aircraft rudder wing components, the laser welding tests was carried out on 3 mm thick GH4169 and 20Cr13 under different welding parameters. X-ray inspection, microstructure observation and tensile test of normal temperature and high temperature were performed on the welds, and the results showed that: when the defocus is +2 mm, the welds with less internal porosity defects can be obtained; when the line energy is less than 100 J/mm, it is beneficial to avoid the occurrence of microscopic hot cracks; when the laser power is 2.2 kW, the welding speed is 30 mm / s and the defocus is +2 mm, the weld with the highest tensile strength at normal temperature can be obtained, moreover, in the larger parameter range, welds with tensile strength of 400 ℃ and 600 ℃ better than 20Cr13 base metals can be obtained.