To observe the effect of long-pulsed Nd:YAG laser in treating venous lakes. Methods: A 1 064 nm long-pulsed Nd:YAG laser (spot size: 5 mm/7 mm, energy: 90～110 J/cm2, pulse duration: 15～30 ms.) was used to treat the patient’s lesions. The desirable clinical endpoint of the treatment was lesions turned pallor and shrunk immediately after the irradiation. Continuous airflow cooling was always applied during the laser treatment. The treatment interval was at least 2 months. Results: Of the 23 patients, 19 of them were treated in one session, 3 of them were treated in two sessions and 1 of them was treated in three sessions. 15(60.9%) of them got excellent results and 9(39.1%)of them got good results. 5(20.8%)of them got hypopigmentation as the side effects. Conclusions: We conclude that it is simple and efficient in treating venous lakes by long-pulsed Nd:YAG laser.