A full dynamic theoretical model was developed to simulate the dynamic evolution of coagulation in tissue, which accounted for the dynamics of the temperature and damage dependence of optical properties, thermal properties and blood perfusion rate. The simulations of the temperature distribution, coagulation depth during laser thermotherapy for full dynamic model are compared with the calculations from other models. The results showed that there are differences in temperature and thermal damage among these models. Therefore, mathematical modeling techniques that simulate laser coagulation may not provide reliable information unless they take into account these dynamic parameters.