A design method for ultra high resolution image systems based on full frame CCD KAF50100 was proposed, in which a mechanical rolling shutter was adopted to control the exposure. The Analog Front End (AFE) chip AD9845B was used to process and digitize the analog output of KAF50100 and the digital image signal from the AFE was buffered and arranged in a block ram of Field Programming Gate Arry(FPGA), then was sent out through a Low Voltage Differential Signaling(LVDS) interface. All the control signals and drive timing signals were generated by the FPGA and the RS422 interface was used to receive command and upload the status of system. The least square method was adopted to correct the non-uniformity from four analog outputs of the CCD sensor. Experiment shows that the CCD sensor KAF50100 can work at a top output speed, its pixel output rate is 4×18 MHz, and the maximum frame rate, output noise and the dynamic range are 1 frame/s, 2.76@12bit and 63.4 dB, respectively. With better flexibility and extendibility, this design method can be widely used in ultra high resolution imaging fields like visible light underwater detection, satellite remote sensing and astronomical observation.