In order to solve the problem of multi-point data acquisition and intelligent monitoring in the family, an indoor data acquisition and monitoring system based on the internet of things is designed and implemented. The whole system takes ARM Cortex-M3 as the core processor, LORA module and WIFI module as the wireless communication equipment, LCD screen as data display terminal, and multi-channel wireless sensor nodes. Each node is connected with multi-channel sensors and control devices for data acquisition, control, display and upload. In order to increase the practicability of the system, the calendar function is added to provide time data for the calendar by acquiring network time or local time. The system is deployed indoors and tested. The experimental results show that the response time of the whole system is short, and the data acquisition and upload can be completed in less than 0.35 s. With the increase of the number of network nodes, the system can accurately identify and automatically complete the data acquisition, upload and equipment control without losing data packing. The whole system has high real-time, stability and security, and can better meet the needs of indoor data acquisition and intelligent control.