To realize rapid calculation of the quantum efficiency of different infrared detectors and evaluate their performance advantages and disadvantages, this paper designed quantum efficiency calculation software for infrared detectors based on MATLAB. The software was developed according to the principles of quantum efficiency calculation for infrared focal plane detectors. It loads the voltage signals collected by the test system and implements quantum efficiency calculation and histogram display functions through callback functions. The results show that, in engineering applications, the calculation software demonstrates good scalability and versatility, enabling rapid evaluation of infrared detector performance.