To improve the radiation detection performance of scintillating fiber, a silica cladding crystal scintillating fiber based on the high performance scintillation crystal LYSO∶Ce is prepared by a modified rod-in-tube method. First, the electron radiation comparison experiment is conducted by using an electron accelerator. The electron radiation responses of the silica cladding LYSO∶Ce scintillating fiber (SLCF) and existing silica cladding YAG∶Ce scintillating fiber (SYCF) are studied. Then, the influences of the fiber length and the distance from the fiber to the radiation source on the radiation sensing characteristics of SLCF are further analyzed. Finally, through the radiation experiment, the repeatability of radiation sensing characteristics of SLCF is tested. Experimental results show that SLCF has excellent electronic radiation response and sensing characteristics.