The laser cleaning technology is utilized to clean anodic oxide film of 2219 aluminum alloy before welding and the effect of cleaning speed on removal effect is studied. In order to verify the feasibility of laser cleaning, we perform the welding experiments on the cleaned aluminum alloy. At last, the mechanism and characteristic of laser cleaning are analyzed. Results indicate that 2219 aluminum alloy can obtain good appearance and internal quality after laser cleaning. The laser cleaning rate threshold is 1079 mm·min-1. The main mechanisms of laser cleaning of 2219 aluminum alloy anodic oxide film are evaporation and explosion, and also accompany with some elastic vibration stripping.