Underwater vehicle optoelectronic device is an important observation and measurement equipment of underwater vehicle, which is affected by the hydrodynamic force of wave and flow field. Under the action of wave and flow field, the optoelectronic device will have periodic bending and vibration.In serious cases, the device may be affected or even damaged. The flow force of optoelectronic device in wave flow field is analyzed and its time domain spectrum is obtained. Then, the maximum deformation and stress response of the underwater vehicle optoelectronic device under the action of wave and flow field are calculated by means of transient dynamic finite element analysis, and the maximum deformation and stress time-domain spectra are obtained. The simulation results show that the dynamic response of vortex lateral force under transient loading is much larger than that under maximum static loading. The mechanical response analysis under the action of wave and flow field is of great significance to the structural strength and application evaluation of device.