The prediction accuracy of orbit-controlled jet is the key technology of high-speed interception weapons.Currently，there are scarce studies on the jet interaction at high altitudes and large Mach numbers，and the law of influence of various physical effects on the jet interaction during high-speed flight in this airspace is not systematic enough.By solving the three-dimensional chemical non-equilibrium Navier-Stokes equation with slip boundary conditions，the influence of the high-temperature thermochemical non-equilibrium effect，gas secondary combustion effect，and rarefied gas effect on the orbit-controlled jet interaction is analyzed，and the influence of various physical effects on the aerodynamic characteristics of the orbit-controlled jet interaction under different flow conditions is obtained.The results indicate that the high-temperature dissociation reaction of the incoming air and gas components is the main factor accounting for the difference between the cold air and hot gas at high altitudes and large Mach numbers，and the influence degree decreases when the altitude increases while increases when the Mach number increases.The influence of the rarefied gas effect on the interaction aerodynamic force/moment of the overall jet is minor.