With the continuous development of the manufacturing industry, aluminum alloy box parts have been widely used in fields such as electronic information, instruments and meters, aerospace. The complex structure and high performance requirement have brought challenges to the manufacturing process. Based on the design for manufacturing (DFM) technology, an in-depth analysis of the manufacturability of aluminum alloy box parts is conducted. By expounding the principle and method of DFM, combining with the characteristics of aluminum alloy box parts, the model based definition technology is used to represent processing and manufacturing information. According to the own manufacturing technology and technology level of enterprises, a process rule library is constructed, and the manufacturability analysis of the three-dimensional product models can be realized. Through the inspection and verification for the manufacturability of the design models, unnecessary design and process changes during the manufacturing stage is avoided, the design quality is enhanced, the design cost is reduced, and the product development cycle is shortened.