Oral mucosal diseases, characterized by diverse etiologies and treatments, remain incurable both domestically and internationally. The unique oral environment often renders conventional treatments ineffective. In contrast, the Nd:YAG laser, known for its strong penetration and therapeutic efficacy, has gained popularity in treating oral mucosal diseases. However, laser parameters currently vary, and no standardized operating guidelines exist. This paper aims to evaluate the application of the Nd:YAG laser in treating oral mucosal disorders and provide a theoretical basis for its practical use.