In this paper, Nd:YAG laser welding machine was used to process research on dual-phase steel. Respectively, three group parameters were selected in current, pulse width and frequency. Orthogonal experiment method was used to analyze the influence of welding quality. Range analysis was carried out on the measurement results. The best parameters selected were: current was 110 A, frequency was 14 Hz and pulse width was 1.4 ms. Furthermore variance analysis was carried out. It was founded that the influence of current on welding quality was more significant than frequency, and the pulse width almost had not influence in this experiment.