This paper introduces the irradiation characteristics of the acousto-optic tunable filter device, the key acousto-optic medium tellurium dioxide crystals and the transducer lithium niobate crystals in the device. The radiation experiments included neutron irradiation (neutron fluence of1.5×1012 n/cm2@1MEV equivalent electrons) and ionizing radiation (total dose of 6×103 Gy(Si)). High-resolution X-ray diffraction (HRXRD) analysis of tellurium dioxide and lithium niobate crystals before and after irradiation showed no change in their X-ray diffraction peaks, indicating that their lattice constants remained unchanged. However, their rocking curves became wider, indicating that the absorbed radiation energy increased internal stresses within the crystals. An impedance analyzer was used to measure the electromechanical coupling coefficient of lithium niobate before and after irradiation, showing that irradiation reduced the electromechanical coupling coefficient by about 1%. Four different wavelengths of lasers, including 1064nm, were used to test the filtering function and diffraction efficiency of the acousto-optic tunable filter devices. The tests indicated that the filtering function was normal, and irradiation caused about a 2% reduction in diffraction efficiency, suggesting that the impact of irradiation on the acousto-optic tunable filters was minimal, making them suitable for deep space exploration under irradiation conditions.