Bi2Sr2Co2Oδ (BSCO) thin films were grown on Al2O3 (0001) substrates by pulsed laser deposition (PLD) technique. Laser induced thermoelectric voltage (LITV) effect was observed in those films on vicinal-cut substrate. The result of X-ray diffraction (XRD) showed that films on untilted Al2O3 (0001) substrates were c oriented. The temperature dependence of the electrical resistivity of films was measured by a standard four probes method, the result showed that films were semiconductor from 80 K to 360 K. The optimal film thickness was found in two tilted substrates with 10° and 15° angles, at which the peak voltage of LITV signals reach 0.4442 V and 0.7768 V respectively. The anisotropy of Seebeck coefficient lead to laser induced thermoelectric voltage signals.