A control system of multi-detector imaging based on CAN bus has been implemented on opto-electronic imaging tracking and measuring device. The field control nodes use DSP chip TMS320F2812 to support the imaging control system, including motor control, sensor control, temperature measurement and control, etc. A real-time communication protocol is designed to meet the data transmission on the system control network, and this protocol can be applied to other device with little change. On the remote host computer, a main control software is programmed to monitor and control the imaging system. Test results and application in devices show that this system is stable and reliable, and it can be promoted to more opto-electronic imaging tracking and measurement devices.