This study investigates the laser drilling of theroplastic materials, focusing on the performance of four different lasers: ultmviolet nanosecond, green nanosecond, CO, continuous, and fiber nanosecond lasers. The ultraviolet nanosecond laser was identified as the most suitable for achieving optimal drilling quality. A systematic analysis was conducted to examine the influence of scanning times and speeds on the drilling quality. The results show that scanning times have obvious effects on diameter and taper of hole, and scanning speeds have obvious effects on diameter, tape, roundness and heat-affected zone of hole. For processing 0. 3 mm through-holes in a 1 mm thick theroplastic, the optimal laser parameters were detennined to be an average power of 10 W, a repetition rate of 60 kHz, zero defocus, 120 processing tines, and a scanning speed of 300 mm/s.