The compact disc (CD) is used as a grating-coupled element in the surface plasmon resonance (SPR) sensor. And the changes in solution concentration are measured by detecting the resonance angle. The results show that the CD grating-coupled SPR sensor′s sensitivity to the glucose solution is low to mass fraction of 3%, and the theoretical resolution is mass fraction of 1%. The resonance curves with different grating periods, grating groove forms and refractive indexes of analyte are simulated and the results show that reducing the grating period or using the sinusoidal grating as coupling element can further improve the sensitivity of the sensor.