Objective: To investigate the clinical efficacy and side effects of the combination therapy of Er∶YAG and Q532 laser on recurrent Café-au-lait Spots. Methods: 16 cases of patients with recurrent Café-au-lait Spots were treated with combination therapy every 8 weeks. Firstly, the Er∶YAG laser was used to precisely vaporize the superficial tissue of lesions, then the lesions were scanned with Q532 nm laser until the treatment area became gray. The appropriate treatment parameters were selected according to the response of the treatment area. Results: Among the 16 patients after 4～9 treatments, 10 cases were cured, 3 cases marked effective, 2 cases moderate effective, 1 cases invalid with a total effective rate of 93.75%. No cases of aggravated pigmentation and scar formation were noted. Conclusion: The combination therapy of Er∶YAG and Q532 laser is an effective and safe treatment to recurrent Café-au-lait Spots.