To study the characteristics of multi-wavelength laser-induced damages in DKDP crystals used in the inertial confinement fusion (ICF) device, a damage test facility is established, in which the DKDP crystals are under the simultaneous irradiation of 1064 nm and 355 nm lasers. The damage pinpoint morphology, density, size, and damage probability under exposure by a combination of different laser fluences are compared and analyzed. When irradiating a sample with 355-nm laser pulses in R-on-1 tests, 1064-nm laser pulses with different fluences are added. The results show that as the 1064-nm laser fluence increases, the laser damage resistance of the sample increases, the damage pinpoint morphology tends to be similar with that when the sample is irradiated by the 1064 nm laser alone, the damage pinpoint density decreases, and the damage pinpoint size increases. As a whole, the coupling conditioning effect is clearly exhibited.