To solve the problem of repairing and remanufacturing for the mechanical parts, the new process method “laser-resistance composite wire cladding” is used for process research in this study. The laser-resistance composite cladding experiments of multi-channel 630 stainless steel wire under different laser powers were carried out on the surface of No.45 steel. The macro morphology, microstructure, microhardness, and wear resistance of the multi-channel repair layer under different laser powers were compared and analyzed. Results show that with the increase of laser power, the surface smoothness of the repaired layer is higher, and the bonding layer with the substrate gradually becomes smooth. Meanwhile, there is an obvious boundary between the repaired layer and the bonding layer. The grain size of the repaired layer gradually refined is increased with the increasing of laser power. Furthermore, the microhardness of the repaired layer gradually is increased while increasing the laser power. When the laser power is 3 000 W, the average microhardness is 1.16 times higher than that when the laser power is 1 800 W. Moreover, the wear resistance of the repaired layer is the highest when the laser power is 3 000 W, where the primary wear forms are abrasive wear and slight adhesive wear.