In this paper, an experimental study of the picosecond pulsed laser processing with constant single pulse energy, different filling distance and processing times was carried out on Co-WC binary cemented carbide with WC particle size of 0.7-0.8 μm and mass fraction of 91.5%-92.0%. It is found that in the range of the filling distance smaller than the light spot width, the filling distance increases, and the processed surface presents a finishing effect with reduced surface roughness, the filling distance decreases, the laser ablation effect on the material increases; the more processing times, the greater the depth of material removal; with the increase of processing times, the surface of the material is passivated and deactivated, and the ablation effect of the laser weakens; through the detection of the residual stress in the laser processing area, it is found that the picosecond laser processing has no obvious effect on the residual stress on the surface of the cemented carbide; pulse laser edge grinding is performed on the secondary cutting edge of the cemented carbide drill, which removes the residual micro-notches of grinding wheel, and obtains better edge quality and rake surface quality.