We simulate the integrated effects of atmospheric aberration, atmospheric turbulence, thermal blooming, random jitter of laser's intensity and phase, speed of wind, direction of wind, absorption of air, kinetic cooling of CO2 and N2, speed of target, output power and beam quality of laser, wavelength, focus length, and the launch altitude of laser to accurately simulate the transmission loss of the laser's energy, concentration of laser's power and other beam quality parameters of the laser propagating to the dynamic target. And we evaluate the efficiency of laser's irradiation on the target more accurately for the optical link of ground-to-airspace. We also investigate influences of characteristics of dynamic parameters (Strehl's ratio, RMS of wave-front, spatial distribution of intensity on the target, the real focus on the optical link and the peak intensity along the propagation path) including speed of wind, direction of wind, speed of target and the kinetic cooling effect of air, especially. We conclude that the higher speed of wind and target weakens the thermal blooming of atmosphere and improves the beam quality and efficiency of laser's irradiation on the target. The kinetic cooling effect of air is more remarkable to improve the beam quality irradiating on the target at the initial part of the propagation path of the laser. The changed direction of wind weakens the atmospheric aberration and directs to better beam quality and higher efficiency of laser's irradiation on the target.