ObjectiveTo establish the evaluation criteria for the rational use of pentoxifylline injection in patients with cerebral infarction(CI) caused by cerebral artery stenosis, and to provide a basis for rational clinical drug use.MethodsBased on the instructions of pentoxifylline injection, relevant guidelines for CI caused by cerebral artery stenosis, and previous literature, the evaluation criteria were formulated. The attribute hierarchy model(AHM) was used to evaluate 292 cases of cerebral artery stenosis CI discharged patients who treated with pentoxifylline injection in our hospital from March 2023 to August 2024.ResultIn the evaluation of the rationality of the results, The relative weights of the indicators, from largest to smallest, are indications(0.1545), dosage and administration(0.1360), contraindications(0.1199), adverse reactions(0.1087), solvent selection(0.1008), drug interactions(0.1002), course of treatment(0.0955), precautions(0.0932), and route of administration(0.0912). Five patients(1.71%) had cases of exceeding contraindications and not following the precautions. Among them, the total deduction score of the visiting department was 106.55 points, with the deduction score for contraindications accounting for 56.26% and the deduction score for precautions accounting for 43.74%. There were 287 cases(98.29%) with excellent case scores and 5 cases(1.71%) with qualified cases. Contraindications and precautions showed significant differences in the score comparison(P<0.001).ConclusionThe use of AHM to evaluate the rationality of pentoxifylline injection in CI patients caused by cerebral artery stenosis has clinical value. The current medication regimens are generally in line with the norms, but improvements are still needed in the screening of contraindications and medication monitoring. It is suggested to optimize management through measures such as strengthening multi-disciplinary collaboration, improving the electronic system for medication contraindications, and enhancing the review of pharmacists' prescriptions and medication education.