Optical coherence tomography (OCT) scattering model and Kubelka-Munk (K-M) theory are combined to analyze the changes of optical parameter quantitively in different aging skin in this paper. In the concrete,the Kun-ming mice with 4 weeks,20 weeks and 40 weeks respective are taken as animal model which imaged by OCT system,the scattering property in mouse skin is responded by OCT backscattering signal in vivo. And the changes of scattering coefficient are gotten by OCT scattering model,and then K-M theory equipment is used to obtain the reduced scattering coefficient in vitro. The outcome indicates that the trends of scattering coefficient obtained from OCT scattering model and the reduced scattering coefficient gotten from the K-M theory in aging mouse skin are uniform,which increases with ages. This result demonstrates that OCT can become a potential tool for detecting the aging skin in clinic in the future,which provides the theoretical basis for studying aging skin and skin cosmetology.