QHS and SRFC were applied to observe the effects of He-Ne laser irradiation on AFC in mice. The results show the spleen region in mice irradiated by He-Ne laser at three-different power levels can increase antibody forming cell activities. The laser irradiated groupwas compared with that of the noemal control group, the difference waa highly significant (P <0.01). The resluts show that laser may have some immunoreguation action.