A pico-ampere voltage reference with high precision was designed. Employing a new type of PVT (process, power, temperature) compensation method, the impact of PVT variations on the circuit performance could be effectively suppressed. Therefore, the stability and accuracy of the proposed voltage reference could be greatly improved while ensuring ultra-low power consumption. The circuit was designed in a standard 018 μm CMOS technology. The simulation results with Spectre showed that the output reference voltage was 7555 mV, the line regulation was 416×10-6/V over the supply voltage range from 09 V to 18 V, the power supply rejection ratio was -955 dB@10Hz, and the 3δ inaccuracy of reference voltage was 011%. The average temperature coefficient was 165×10-5/℃ over the temperature range from -20 ℃ to 120 ℃. The typical operating current was 347 pA at room temperature. This voltage reference had excellent performance for low-power IoT application systems.