The reliance on imported high-precision measurement instruments in nuclear engineering construction has been challenged by the evolving international environment, impacting procurement for some enterprises. Consequently, there is a drive towards the domestic development of autonomous and controllable measurement equipment. This study focuses on the application of such equipment in the main pipeline detection of nuclear power plants, using system research and development as a foundation for on-site implementation. The operational key points are identified through the analysis of implementation concepts, and a main pipeline detection process flow is established based on field application. Comparative testing with a laser tracker assesses measurement accuracy, range, and repeatability. The system, characterized by non-contact measurement and real-time data feedback, can rapidly acquire extensive data through close-range shooting. It achieves a measurement accuracy of 0.14 mm, surpassing the 0.3 mm installation measurement requirement, and thus, better satisfies on-site needs. The findings indicate the feasibility of this system as a domestic alternative to high-precision measurement instruments in the nuclear engineering sector.